PrP expression level and sensitivity to prion infection.
نویسندگان
چکیده
Mice overexpressing the prion protein (PrP) sequence from various host species are widely used for measuring infectious titers in prion disease. However, the impact that the transgene expression level might have on the susceptibility to infection raises some concerns about the final biological relevance of these models. Here we report that endpoint titration of a sheep scrapie isolate in sheep and in mice overexpressing the ovine PrP results in similar estimates of the infectious titer.
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ورودعنوان ژورنال:
- Journal of virology
دوره 88 10 شماره
صفحات -
تاریخ انتشار 2014